Adult Stem Cell Medicine Patents

Asymmetrex has produced a diverse portfolio of adult stem cell medicine patents and pending patent applications for new technologies for mass-producing diverse types of human adult stem cells, and for identifying them and their mature cell derivatives. The expanded adult stem cells retain their ability to produce their respective functional human tissues cells, allowing mass-production of a wide array of human cells for research, pre-clinical studies, and clinical applications. These cell technologies and stem cell patents are the outgrowth of the research of the Asymmetrex’s Director, Dr. James L. Sherley. They are the culmination of twenty years of research led by Dr. Sherley at the Fox Chase Cancer Center in Philadelphia, the Massachusetts Institute of Technology, and most recently the Boston Biomedical Research Institute. In recognition of the superior innovation of this research, in 2006, Dr. Sherley received a National Institutes of Health Director’s Pioneer Award. Under Dr. Sherley’s directorship, Asymmetrex will work with life science companies to craft these novel technologies to address their specific barriers to commercialization of human cell products and applications.

Issued Adult Stem Cell Medicine Patents

2019 Methods for Determining the Effect of an Agent on Tissue Stem Cells – GB 2529921

2017 Methods for Determining the Effect of an Agent on Tissue Stem Cells – US 9,733,236

2015 Detecting and Counting Tissue-Specific Stem Cells and Uses Thereof – US 9,081,008

2014 Method for Cloning Pluripotent Stem Cells – US 8759098

2013 Hepatocyte Precursor Cell Lines – US 8404481

2011 Unique Properties of Stem Cells – US 7883891

2010 Nucleic Acid Sequences Associated with Cell States – US 7867712

2010 Methods for Ex Vivo Propagation of Adult Hepatic Stem Cells – US 7824912

2010 Methods for Ex Vivo Propagation of Somatic Hair Follicle Stem Cells – US 7655465

2010 Hepatocyte Precursor Cell Lines – US 7645610

Published Pending Patent Applications

2014 Methods for Producing Human Pancreatic Islet Precursor Cells and Uses Thereof- No. PCT/US2012/042644


Adult Stem Cell Publications

Asymmetrex founder Dr. James Sherley and the Asymmetrex scientists have a significant body of published research on adult stem cells and adult stem cell medicine.

A Computational Simulation Technology for Specific Counting of Perinatal and Postnatal Human Tissue Stem Cells for Transplantation Medicine

A Computational Simulation Technology for Specific Counting of Perinatal and Postnatal Human Tissue Stem Cells for Transplantation Medicine

-- Renly Dutton, Frank Abdi, Levon Minnetyan, James L. Sherley

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Dose Determination for Stem Cell Medicine: A Need Whose Time Has Come in Perinatal Stem Cells: Research and Therapy

Dose Determination for Stem Cell Medicine: A Need Whose Time Has Come in Perinatal Stem Cells: Research and Therapy

-- James L. Sherley, M.D., Ph.D., edited by Anthony Atala, Kyle J. Cetrulo, Rouzbeh R. Taghizadeh, Sean V. Murphy, Curtis L. Cetrulo Jr.

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Sparse Feature Selection Identifies H2A.Z as a Novel, Pattern-Specific Biomarker for Asymmetrically Self-Renewing Distributed Stem Cells

Sparse Feature Selection Identifies H2A.Z as a Novel, Pattern-Specific Biomarker for Asymmetrically Self-Renewing Distributed Stem Cells

-- Yang Hoon Huh, Minsoo Noh, Frank R. Burden, Jennifer C. Chen, David A. Winkler, James L. Sherley, M.D., Ph.D., Published in Stem Cell Research

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Accelerating Progress in Regenerative Medicine by Advancing Distributed Stem Cell-based Normal Human Cell Biomanufacturing

Accelerating Progress in Regenerative Medicine by Advancing Distributed Stem Cell-based Normal Human Cell Biomanufacturing

-- James L. Sherley, M.D., Ph.D., Published in Pharmaceutica Analytica Acta

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New cancer diagnostics and therapeutics from a ninth ‘hallmark of cancer’: symmetric self-renewal by mutated distributed stem cells

New cancer diagnostics and therapeutics from a ninth ‘hallmark of cancer’: symmetric self-renewal by mutated distributed stem cells

-- James L. Sherley, M.D., Ph.D., Published in Informa Healthcare

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Ex vivo Expansion of Human Adult Pancreatic Cells with Properties of Distributed Stem Cells by Suppression of Asymmetric Cell Kinetics

Ex vivo Expansion of Human Adult Pancreatic Cells with Properties of Distributed Stem Cells by Suppression of Asymmetric Cell Kinetics

-- James L. Sherley, M.D., Ph.D., Published in Journal of Stem Cell Research & Therapy

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Higher 5-hydroxymethylcytosine identifies immortal DNA strand chromosomes in asymmetrically self-renewing distributed stem cells

Higher 5-hydroxymethylcytosine identifies immortal DNA strand chromosomes in asymmetrically self-renewing distributed stem cells

-- Yang Hoon Huha, Justin Cohenb, and James L. Sherley, Published in Proceedings of the National Academy of Sciences

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Advancing renewable normal human cell assays for drug discovery

Advancing renewable normal human cell assays for drug discovery

-- James L. Sherley, M.D., Ph.D., Published in Wiley Online Library and Drug Development Research

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Nature- Comment on Steinhauser et al., 2012

Nature- Comment on Steinhauser et al., 2012

-- James L. Sherley, Published in Nature

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Tissue Stem Cells. In: Schwab M. (Ed.) Encyclopedia of Cancer. Springer-Verlag Berlin Heidelberg, 2009. DOI: 10.1007/SpringerReference_177486 2012-05-16 22:47:18 UTC

Tissue Stem Cells. In: Schwab M. (Ed.) Encyclopedia of Cancer. Springer-Verlag Berlin Heidelberg, 2009. DOI: 10.1007/SpringerReference_177486 2012-05-16 22:47:18 UTC

-- James L. Sherley, M.D., Ph.D., Published in Encyclopedia of Cancer

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Overlooked areas need attention for sound evaluation of DNA strand inheritance patterns in Drosophila male germline stem cells

Overlooked areas need attention for sound evaluation of DNA strand inheritance patterns in Drosophila male germline stem cells

-- James L. Sherley, Published in Journal of Cell Science

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A Resource for Discovering Specific and Universal Biomarkers for Distributed Stem Cells

A Resource for Discovering Specific and Universal Biomarkers for Distributed Stem Cells

-- Minsoo Noh, Janet L. Smith, Yang Hoon Huh, and James L. Sherley, M.D., Ph.D., Published in PLOS | ONE

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CXCR6, a Newly Defined Biomarker of Tissue-Specific Stem Cell Asymmetric Self-Renewal, Identifies More Aggressive Human Melanoma Cancer Stem Cells

CXCR6, a Newly Defined Biomarker of Tissue-Specific Stem Cell Asymmetric Self-Renewal, Identifies More Aggressive Human Melanoma Cancer Stem Cells

-- Rouzbeh Taghizadeh, Minsoo Noh, Yang Hoon Huh, Emilio Ciusani, Luca Sigalotti, Michele Maio, Beatrice Arosio, Maria R. Nicotra, PierGiorgio Natali and James L. Sherley Published in PLOS | ONE

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CFP and YFP, but Not GFP, Provide Stable Fluorescent Marking of Rat Hepatic Adult Stem Cells

CFP and YFP, but Not GFP, Provide Stable Fluorescent Marking of Rat Hepatic Adult Stem Cells

-- Rouzbeh R. Taghizadeh and James L. Sherley, M.D., Ph.D., Published in Journal of Biomedicine and Biotechnology

More Published Research

Click here to see an abridged listing of Asymmetrex’s and Dr. Sherley’s published research.

AsymmetrexPatents and Publications