First Ever Technology For Counting Adult Stem Cells

The AlphaSTEM Test is the first-ever technology for counting adult tissue stem cells, available only from Asymmetrex, the leader in innovative technologies for stem cell medicine. The AlphaSTEM Test is for amniotic fluid stem cell treatments, umbilical cord blood transplantation medicine, drug safety testing, stem cell transplantation medicine, regenerative medicine clinical trials, gene editing therapeutics development, and stem cell basic research.

Drug Safety Testing
Many drug candidates fail safety requirements in expensive animal studies and clinical trials because of inducing chronic or sub-chronic organ failure, which are due to their toxicity against tissue stem cells. The AlphaSTEM Test can identify such future failing unsafe drug candidates much earlier and at greatly reduced cost.

  • Identify tissue stem cell-toxic drug candidates that are likely to cause organ failure.
  • Unlike existing unspecific tests, distinguish effects on stem cells from effects on other cell types.

Stem Cell Transplantation Medicine

Transplanted adult tissue stem cells have the ability to repair injured tissues and restore diseased or aging organs and tissues to better health. The AlphaSTEM Test improves the quality of stem cell transplant therapies by making it possible, for the first time, to standardize the dose of the treating tissue stem cell. Examples of counted stem cells include bone marrow-derived mesenchymal stem cells, fat-derived mesenchymal stem cells, amniotic fluid stem cells, and hematopoietic stem cells.

  • Determine the dose of tissue stem cells in treatment preparations from any human tissue.
  • Unlike existing unspecific tests, distinguish long-term stem cells from short-term progenitor cells.

Umbilical Cord Blood Transplantation Medicine
Transplanted hematopoietic stem cells found in umbilical cord blood have the ability to rescue children from high dose chemotherapy treatments given to eradicate cancers like leukemia. The AlphaSTEM Test can alleviate the current pervasive and pernicious uncertainty of whether a cord blood sample will have enough hematopoietic stem cells to rescue a child treated for leukemia.

  • Determine the number of hematopoietic stem cells in cord blood samples used for rescue treatment.
  • Unlike existing unspecific tests, distinguish long-term stem cells from short-term progenitor cells.

Regenerative Medicine Clinical Trials
Transplanted adult tissue stem cells have the ability to repair injured tissues and restore diseased or aging organs and tissues to better health. The AlphaSTEM Test improves the quality of regenerative medicine clinical trials by making it possible, for the first time, to relate clinical outcomes to the dose of treating tissue stem cells.

  • Determine the dose of tissue stem cells in treatment preparations from any human tissue.
  • Unlike existing unspecific tests, distinguish long-term stem cells from short-term progenitor cells.

Gene Editing Therapeutics Development
Gene editing of adult tissue stem cells, whose targeting is crucial of therapeutic success, is currently performed with tissue cell preparations in which the stem cell number is unknown and may be inadequate. The AlphaSTEM Test can accelerate development of gene editing therapeutics by making it possible, for the first time, to determine the number of active tissue stem cells before and after gene editing.

  • Determine the number of tissue stem cells available for editing and the dose of edited stem cells.
  • Unlike existing unspecific tests, distinguish long-term stem cells from short-term progenitor cells.

Stem Cell Basic Research
Adult tissue stem cells are responsible for the renewal and repair of postnatal vertebrate tissues; after transplantation they have the ability to repair injured tissues and restore diseased or aging organs and tissues to better health. The AlphaSTEM Test is an important new tool for basic research that, for the first time, allows experimental effects of adult tissue stem cells to be related directly to their number.

  • Determine the number of adult tissue stem cells in complex experimental culture preparations.
  • Unlike common unspecific biomarkers, distinguish tissue stem cells from committed progenitor cells.

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